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Hydroxypropyl and acrylamide are two common chemicals that have significant differences in their chemical structure and applications. Hydroxypropyl acid, also known as 3-hydroxypropionic acid, is a colorless liquid and an important organic synthetic raw material, mainly used in the manufacturing of coatings, resins, textiles, and pharmaceuticals. Hydroxypropyl has a certain hydrophilicity and activity due to its chemical structure containing hydroxyl and acetone groups. Acrylamide is a colorless liquid or solid and an important chemical raw material, mainly used for the preparation of polyacrylamide. The chemical structure of acrylamide contains an acrylic group, which is an alkene compound. The difference in molecular structure between the two determines their differences in properties and applications. Hydroxypropyl has high hydrophilicity, is soluble in water, and has active groups, making it prone to chemical reactions with other substances. Acrylamide, on the other hand, has strong unsaturated properties and is easy to polymerize into polymers, exhibiting excellent high temperature and corrosion resistance. In industrial production and application, hydroxypropyl is mainly used to prepare resins and coatings, while acrylamide is mainly used to prepare polymers and biomedicine. Overall, there are significant differences in chemical structure and usage between hydroxypropyl and acrylamide, which require strict differentiation during use. The correct use of chemicals can better exert their effects and avoid unnecessary safety risks. I hope this article can help readers better understand the difference between hydroxypropyl and acrylamide, and be helpful for the correct classification and use of chemicals.