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Formic acid is a common simple fatty acid with extensive applications in chemical production. The addition and absence of formic acid in the mobile phase have different effects and effects in chemical production. Next, we will delve deeper into the differences between these two situations

Let's take a look at the addition of formic acid to the mobile phase. In chemical production, mobile phase is usually used to help accelerate reaction rate and improve reaction efficiency. After adding formic acid, the mobile phase will envelop formic acid molecules, increasing the contact area between formic acid molecules, thereby accelerating the reaction rate with other reactants and improving the rate of product generation. In addition, the mobile phase can also make formic acid more stable during the reaction process, reducing the possibility of side reactions and thus improving the selectivity of the reaction. Therefore, when formic acid is added to the mobile phase, higher product yields and purer products can be obtained

On the contrary, if the mobile phase is not added and formic acid is directly used for the reaction, some different situations will occur. Due to the absence of a mobile phase envelope, the contact area between formic acid molecules is small, which can affect the reaction rate to a certain extent, resulting in a slower rate of product generation. In addition, without the stabilizing effect of the mobile phase, formic acid is easily affected by some unfavorable factors during the reaction process, which increases the possibility of side reactions and reduces the selectivity of the reaction. Therefore, without the addition of mobile phase, the product yield and purity are often affected to a certain extent

Overall, both the presence and absence of formic acid in the mobile phase have their own characteristics and effects. It is very important to choose the appropriate addition method based on specific reaction requirements and product requirements. We hope that through the introduction in this article, readers can better understand the difference between adding and not adding formic acid mobile phase, and provide certain reference value for practical production applications.