Fumaric acid, also known as transbutyleneglycolic acid, is an important organic chemical raw material, widely used in medicine, pesticide, plastics, rubber and other fields. In the field of chemical production raw materials, fumaric acid manufacturing method mainly has two kinds of chemical synthesis method and biological fermentation method.
I. Chemical synthesis method
1. Hydrolysis of maleic anhydride: this method is to use maleic anhydride as raw material, hydrolyzed under acidic conditions to produce fumaric acid. The specific operation is to mix maleic anhydride with a certain amount of water, add sulfuric acid as a catalyst, and carry out the reaction under heating conditions. After the reaction, the fumaric acid product is obtained by cooling crystallization, filtration, drying and other steps.
2. Olefin oxidation method: This method uses olefins (such as ethylene, propylene, etc.) as raw materials to produce fumaric acid through oxidation reaction. The specific operation is to mix olefin with oxygen, add catalyst, and carry out the reaction under high temperature and high pressure. After the reaction, the fumaric acid product is obtained through cooling, separation, purification and other steps.
II. Bio-fermentation method
Bio-fermentation method is the method of producing fumaric acid by utilizing microbial fermentation. The specific operation is to mix glucose, corn syrup and other nutrients with the right amount of water, inoculate fumaric acid production bacteria, and carry out fermentation under the appropriate temperature, pH value and other conditions. After fermentation, a fumaric acid product is obtained by centrifugation, filtration and other steps.
Compared with the chemical synthesis method, the biological fermentation method has the advantages of mild conditions, simple operation and low cost, etc. However, at present, the acid production rate and conversion rate of the biological fermentation method are relatively low, which still need further research and improvement.
Regardless of which method is used to manufacture fumaric acid, the reaction conditions need to be strictly controlled to ensure product quality and production safety. At the same time, factors such as environmental protection and sustainable development also need to be considered in the production process to promote the development of chemical production in the direction of green, efficient and sustainable.
In conclusion, the manufacturing methods of fumaric acid are mainly chemical synthesis and biological fermentation, different methods have their own advantages and disadvantages, and the suitable method should be selected according to the specific production situation and demand. In the future development, with the continuous progress and application of technology, the manufacturing method of fumaric acid will be more perfect and optimized, and make greater contribution to the development of chemical production field.
