Manufacturing method of o-tert-butylcyclohexanol
O-tert-Butylcyclohexanol (OTBCH) is an important raw material for the production of chemicals, which is widely used in the fields of fine chemicals, pharmaceuticals and pesticides. In this paper, we will introduce an effective manufacturing method of o-Tert-Butylcyclohexanol.
I. Raw materials and equipment
1. Raw materials: cyclohexanone, tert-butanol, sodium hydroxide, water.
2. Equipment: reaction kettle, stirrer, thermometer, condenser, dispensing funnel, vacuum pump and so on.
2. Manufacturing steps
1. Addition reaction: add cyclohexanone and tert-butanol into the reactor according to a certain ratio, heat and stir, so that they fully react to produce o-tert-butylcyclohexanone.
2. Catalytic hydrogenation: add a certain amount of catalyst (such as nickel, palladium, etc.) into the reaction kettle, pass in hydrogen, heat and stir, so that o-tert-butylcyclohexanone will be hydrogenated under the action of catalyst to produce o-tert-butylcyclohexanol.
3. Post-treatment: After the reaction is finished, the reactor is cooled, the reaction solution is poured into a dispensing funnel and washed with water to separate the organic phase. The organic phase is evacuated by vacuum pump to remove the residual water, and the crude o-tert-butylcyclohexanol is obtained.
4. Refining: the crude o-tert-butylcyclohexanol is distilled, and the products of the specified fractions are collected, i.e. o-tert-butylcyclohexanol with higher purity is obtained.
3. Precautions
1. Strictly control the reaction temperature and stirring speed to ensure the reaction proceeds smoothly.
2. The type and dosage of catalyst need to be selected according to the specific reaction conditions and the requirements of the target product.
3. In the post-treatment process, make sure the water is removed to avoid affecting the product quality.
4. Appropriate vacuum and distillation temperature should be maintained during the distillation process to obtain high quality o-tert-butylcyclohexanol. Safety and environmental protection
1. Strictly observe laboratory safety regulations, wear protective gears and avoid direct contact with raw materials and products during operation.
2. For the waste generated, it should be classified and disposed of, following the environmental protection requirements to avoid pollution to the environment.
V. Yield and quality control
1. Yield improvement: The yield of o-tert-butylcyclohexanol can be improved by optimizing the reaction conditions (such as temperature, stirring speed, raw material ratio, etc.). In addition, the choice and dosage of catalyst will also affect the yield, so experimental optimization is needed.
2. Quality control: In order to ensure the quality of the product, the purity, moisture, chromaticity and other indexes of o-tert-butylcyclohexanol need to be tested. The product can be analyzed qualitatively and quantitatively by gas chromatography, mass spectrometry and other analytical methods. At the same time, the intermediates in each step of the production process should also be tested for quality to ensure the stability and reliability of the whole process.
VI.Application Fields and Market Prospects
o-TBu cyclohexanol, as an important chemical raw material, has a wide range of applications in the fields of fine chemicals, pharmaceuticals, pesticides and so on. For example, it can be used as an intermediate in the synthesis of certain drugs and pesticides, and can also be used in the production of spices, plastic additives and so on. With the continuous development of science and technology, the application fields of o-tert-butylcyclohexanol will continue to expand, and the market prospect is broad.
Summary
This paper describes an effective manufacturing method of o-tert-butylcyclohexanol, including the steps of addition reaction, catalytic hydrogenation, post-treatment and refining. Safety matters and environmental protection requirements need to be paid attention to during the operation, while the reaction conditions and catalyst selection are optimized to improve the yield. Through strict control of product quality, high quality o-TBCH can be obtained, which provides important raw material support for fine chemicals, pharmaceuticals, pesticides and other fields.
