Manufacturing method of p-methyl anisole
I. Introduction
p-methyl anisole is an important raw material for the production of chemicals, which is widely used in the fields of pharmaceuticals, pesticides, spices and so on. Therefore, it is of great significance to study the manufacturing method of p-toluidine. In this paper, a common manufacturing method of p-toluidine will be introduced.
II. Materials and equipment
1. Materials: p-toluene, sulfuric acid, methanol.
2. Equipment: reactor, condenser, water separator, stirrer, thermometer, pH meter.
3. Manufacturing steps
1. Add p-methylphenol into the reactor and add appropriate amount of sulfuric acid as catalyst.
2. Turn on the stirrer, slowly add methanol dropwise, control the reaction temperature at 60-70℃, and divide water in time during the reaction.
3. At the end of the reaction, the reaction solution was cooled to room temperature and neutralized with alkali solution to neutral.
4. Remove the organic phase by layering, wash with water until neutral, then dry with anhydrous sodium sulfate.
5. Filter, distill and collect the fraction of p-toluidine.
4. Precautions
1. Control the reaction temperature to avoid too high or too low.
2. Remove water in time during water separation to avoid affecting the reaction.
3. Control the pH value in the neutralization process to avoid over-acid or over-base.
4. The temperature and pressure should be controlled during distillation to avoid decomposition of products or mixing of impurities.
V. Conclusion
By the esterification reaction between p-methylphenol and methanol catalyzed by sulfuric acid, p-methylanisole can be made. The method is easy to operate, with high yield, and is suitable for industrialized production. In the production process, attention should be paid to controlling the reaction conditions to ensure the product quality.
The above is a common manufacturing method of p-toluene anisole, the specific operation process needs to be adjusted and optimized according to the actual situation. At the same time, in order to ensure the safety and environmental protection of the production process, it is also necessary to strictly abide by the relevant laws and regulations, and strengthen the production management and waste disposal. We hope that this article can provide some reference and help to workers engaged in the field of chemical production.
