Dihydroxymethylbutyric acid (DHMBA) is an important organic chemical raw material, widely used in medicine, pesticides, plastics, coatings and other fields. The following is the manufacturing method of DHMBA:
I. Preparation of raw materials
The main raw materials for manufacturing DHMBA are succinic acid, formaldehyde and sodium hydroxide. Among them, succinic acid can be obtained by biological fermentation or chemical synthesis, and formaldehyde and sodium hydroxide are both common chemical raw materials.
II. Reaction process
1. Reaction between succinic acid and formaldehyde: Add succinic acid and formaldehyde into the reactor according to a certain molar ratio, heat to a certain temperature, stir for a certain period of time, so as to make succinic acid and formaldehyde fully reacted to produce dihydroxymethylbutyric acid monomer.
2. Neutralization reaction: add sodium hydroxide solution to the above reaction solution, adjust the pH to neutral, so that the generated dihydroxymethylbutyric acid monomer is precipitated in the form of salt.
3. Separation and purification: Recrystallize the precipitated dihydroxymethylbutyric acid salt with ethanol or water to obtain dihydroxymethylbutyric acid product with high purity.
3. Precautions
1. Control the reaction temperature and time: the reaction between succinic acid and formaldehyde needs a certain temperature and time, but avoid too high temperature and too long time leading to the decomposition of the product and the generation of by-products.
2. Adjustment of pH: Appropriate amount of sodium hydroxide solution needs to be added during the neutralization reaction to adjust the pH to neutral in order to ensure the generation and precipitation of dihydroxymethylbutyric acid.
3. Selection of purification method: choose the suitable purification method according to the specific situation to ensure the purity and yield of the product.
In short, the manufacturing method of dihydroxymethylbutyric acid needs to control the reaction conditions, adjust the pH value and select the suitable purification method, etc. to ensure the quality and yield of the product.
