Manufacturing method of bromoacetone
I. Introduction
Bromoacetone is an important organic synthesis intermediate, widely used in the production of pharmaceuticals, pesticides, spices and other chemicals. In this paper, we will introduce a manufacturing method of bromoacetone, which has the advantages of easy operation, high yield and good safety.
II. Experimental principle
The manufacture of brominated acetone is through the electrophilic substitution reaction between acetone and bromine under alkaline condition to produce brominated acetone. The reaction equation is as follows:
CH3COCH3 + Br2 → CH3COCH2Br + HBr
III.Experimental Procedure
1. Add acetone into the reactor, turn on the stirring, and control the temperature at 10-15℃.
2. Slowly add aqueous sodium hydroxide solution and adjust the pH to alkaline.
3. Slowly add bromine dropwise with stirring, controlling the rate of dropwise acceleration so that the reaction temperature does not exceed 25℃.
4. After dropwise addition, continue stirring for 2-3 hours to allow the reaction to proceed fully.
5. At the end of the reaction, pour the reaction solution into a separatory funnel and wash with water until neutral.
6. Separate the organic phase and dry with anhydrous sodium sulfate.
7. Filter, distill and collect the bromoacetone product.
4. Precautions
1. Bromine is strongly corrosive, wear protective gear during operation and avoid contact with skin.
2. Strict temperature control is required during the reaction process to prevent high temperature from triggering side reactions. 3. Ensure that the washing process is neutral to avoid alkaline impurities in the product.
4. The distillation speed should be controlled to avoid decomposition of the product.
V. Experimental Results and Discussion
1. Experimental Results
The bromoacetone manufactured by this method can achieve a yield of more than 90% and a product purity of more than 98%.
2. Discussion of results
The present method carries out the bromination reaction under alkaline condition, which can effectively improve the yield. Meanwhile, controlling the reaction temperature and pH value can avoid the occurrence of side reactions and improve the product purity. In addition, this method is easy to operate, safe and suitable for industrial production.
VI.CONCLUSION
In this paper, a manufacturing method of bromoacetone was introduced, which has the advantages of easy operation, high yield and good safety. Through experimental verification, the method can prepare high purity brominated acetone, which is suitable for industrialized production.
