Manufacturing Method of Tert-Butyl Acetophenone
Tert-Butyl Acetophenone (TBA) is an important organic chemical raw material, which is widely used in the fields of medicine, pesticide, spice, plastics and so on. This article will introduce the manufacturing method of Tert-Butyl Acetophenone in detail, including raw material preparation, reaction process, post-treatment and precautions.
I. Raw material preparation
The main raw materials for manufacturing tert-butyl acetophenone are acetophenone and isobutylene. Among them, acetophenone can be produced by reacting benzene with acetic anhydride, and isobutylene can be obtained by methods such as naphtha cracking or propylene dimerization.
II. Reaction process
The manufacturing method of tert-butyl acetophenone mainly adopts alkylation reaction, i.e., isobutylene is reacted with acetophenone under the action of an acidic catalyst. The specific steps are as follows:
1. Mix acetophenone and isobutene in the ratio of molar ratio 1:1.05~1.1, and add to the reactor.
2. adding an appropriate amount of an acidic catalyst, such as sulfuric acid, hydrofluoric acid, etc., to the reactor.
3. Control the reaction temperature at 50~70°C and the reaction pressure at 0.5~1.0 MPa for alkylation reaction.
4. Samples should be taken and analyzed at regular intervals during the reaction process, and the raw material ratio and reaction conditions should be adjusted according to the analytical results, so as to ensure the yield and purity of tert-butyl acetophenone.
Three, post-processing
After the reaction is finished, post-processing is needed to get pure tert-butyl acetophenone products. The specific steps are as follows:
1. Pour the reaction solution in the reactor into a dispensing funnel and wash with water to remove the acidic catalyst and unreacted raw materials.
2. The organic phase is dried with anhydrous sodium sulfate and filtered to remove the desiccant.
3. Separate tert-butyl acetophenone from the organic phase by distillation and collect the fraction with higher purity.
4. Precautions
1. Attention should be paid to safety during operation, avoiding contact with acidic catalysts and high-temperature and high-pressure equipment.
2. The raw materials acetophenone and isobutene are flammable and explosive substances, they should be stored in a cool and ventilated place, away from fire and heat sources.
3. Reaction conditions and raw material ratios should be strictly controlled in the manufacturing process to improve the yield and purity of tert-butyl acetophenone.
4. Waste should be properly disposed of to avoid pollution to the environment.
In conclusion, the manufacturing method of tert-butyl acetophenone involves many aspects such as raw material preparation, reaction process, post-treatment, etc., which requires strict control of reaction conditions and operation process to ensure the quality and yield of the product. At the same time, attention should be paid to safety and environmental protection during operation to avoid harming the environment and personnel.
