Method of manufacturing tert-butyl phenylacetone
Tert-butyl phenylacetone (TBAP) is an important organic compound widely used as a raw material for chemical production. It has unique chemical properties and can be used to manufacture a wide range of polymer materials and fine chemicals. This article will introduce the manufacturing method of tert-butyl phenylacetone in detail.
I. Raw materials and equipment
1. Raw materials: phenylacetone, tert-butyl alcohol, sulfuric acid, sodium hydroxide, water and so on.
2. Equipment: reaction kettle, condenser, water separator, stirrer, thermometer, pH meter and so on.
2. Manufacturing steps
1. tert-butylation reaction
Add acetophenone and tert-butanol to the reaction kettle according to the molar ratio of 1:1.2, add a small amount of sulfuric acid as a catalyst. Heat the reaction kettle to 80-90℃ and stir the reaction for 4-6 hours. During the reaction, separate water in time to ensure the smooth progress of the reaction. After the reaction, cool to room temperature and adjust the pH to neutral with sodium hydroxide solution.
2. Extraction and Separation
The reaction solution was poured into a partition funnel, appropriate amount of water was added, and extraction was carried out with ether. Repeat the extraction 2-3 times and combine the ether layers. The ether layer was washed with water to neutral and dried with anhydrous sodium sulfate. After filtration, the ether was recovered by distillation to obtain crude tert-butyl phenylacetone.
3. Refining
The crude tert-butylpropiophenone was added to a distillation kettle and distilled under vacuum. Collect the fractions within the boiling point range to obtain pure tert-butylpropiophenone.
III. Precautions
1. Strictly control the reaction temperature to avoid side reaction at high temperature.
2. The water separator should be drained in time to prevent moisture accumulation affecting the reaction.
3. Ensure adequate mixing during extraction to improve extraction efficiency.
4. Anhydrous sodium sulfate should be used in the drying process to ensure the product is dry.
5. Appropriate vacuum should be maintained during the refining process to avoid product decomposition.
4. Yield and quality
Manufacture tert-butyl phenylacetone according to the above method, the yield can reach 80-85%. The purity of the product can reach more than 98%, which meets the requirements of chemical production.
V. Safety and environmental protection
1. Strictly follow the safety operation regulations during the production process to ensure the safety of employees and equipment.
2. For the waste water, waste gas and other pollutants generated, they should be properly treated and discharged after meeting the requirements of environmental protection.
3. For the waste materials and by-products, they should be reasonably utilized or safely treated to avoid pollution to the environment.
VI. Summary and Prospect
Tert-butyl acetophenone, as an important raw material for the production of chemicals, has a wide range of application prospects. The manufacturing method introduced in this paper has the advantages of easy operation, high yield and good product quality, which is suitable for industrialized production. With the continuous development of science and technology, new manufacturing process and green production technology can be further explored in the future to improve the production efficiency and environmental friendliness of tert-butylpropiophenone, and contribute to the sustainable development of the chemical industry.
