Manufacturing method of Ethyl isobutyl acetophenone
Ethyl isobutyl acetophenone (EBBE) is an important organic chemical raw material, which is widely used in the fields of pharmaceuticals, pesticides, and spices. This article will introduce a common manufacturing method of ethyl isobutyl acetophenone.
I. Raw materials and equipment
1. Raw materials: acetophenone, isobutanol, sulfuric acid, sodium hydroxide.
2. Equipment: reactor, condenser, water separator, stirrer, thermometer, pH meter.
2. Manufacturing steps
1. Esterification reaction of acetophenone and isobutanol
Add acetophenone and isobutanol in the reactor and stir well. Then sulfuric acid was added slowly as a catalyst. The reaction kettle was heated, keeping the temperature between 80-100°C, and the reaction was carried out for about 4-6 hours. Separate out the water generated by means of a water separator while recovering the unreacted acetophenone and isobutanol by means of a condenser.
2. Neutralization and decolorization of esterification products
After the reaction is completed, the reaction solution is cooled to room temperature and then neutralized with sodium hydroxide solution to a pH of 7-8. Afterwards, activated charcoal is added for decolorization, and the activated charcoal is filtered off after stirring for about 30 minutes.
3. Distillation and purification
The filtrate was distilled and the fraction with boiling point between 170-180°C was collected as ethyl isobutyl acetophenone.
3. Precautions
1. Strictly control the reaction temperature to avoid too high or too low.
2. When adding sulfuric acid catalyst, operate carefully to avoid splashing.
3. In the process of neutralization, add sodium hydroxide solution slowly and stir constantly to avoid local over-base.
4. In the process of decolorization, the dosage of activated carbon should be appropriate, too much will affect the product yield, too little will have poor decolorization effect.
4. Safety and environmental protection
1. Pay attention to safety in the operation process, wear good protective equipment and avoid contacting chemicals. Waste water, waste gas and other pollutants should be treated to meet environmental standards before discharge.
V. Product quality and yield
Through the above manufacturing method, ethyl isobutyl acetophenone with high purity can be obtained, and the yield is generally between 80-90%. The test of product quality can be carried out by gas chromatography and other methods.
VI. Optimization and improvement
In order to improve the yield and purity of ethyl isobutyl acetophenone, some optimization and improvement can be carried out on the manufacturing method:
1. Adopt more efficient catalysts: some catalysts with higher activity and better selectivity can be chosen to improve the reaction rate and product selectivity.
2. Optimize the reaction conditions: the reaction efficiency and product quality can be further improved by adjusting the parameters such as reaction temperature, pressure and stirring speed.
3. Enhance wastewater treatment: the generated wastewater can be treated more effectively to reduce the pollution to the environment.
In conclusion, the manufacturing method of ethyl isobutyl acetophenone is not complicated, but to obtain high-quality products, it is necessary to strictly control the process conditions of each link, pay attention to safety and environmental protection, and constantly optimize and improve the manufacturing method.
