Propyl tert-butyl acetophenone (PTBA) is an important raw material for the production of chemicals, which is widely used in the fields of pharmaceuticals, pesticides and spices. In this paper, a manufacturing method of propyl tert-butyl acetophenone will be introduced.
I. Raw materials and equipment
1. Raw materials: acetophenone, tert-butanol, propylene, catalyst (sulfuric acid or phosphoric acid)
2. Equipment: reaction kettle, condenser, water divider, stirrer, thermometer, manometer
II. Manufacturing steps
1. Add acetophenone and tert-butanol into reaction kettle according to a certain molar ratio, and stir well.
2. Add catalyst, continue stirring, warm up to a certain temperature, keep constant temperature reaction for a certain time.
3. During the reaction, the water generated is separated by a water separator and the unreacted tert-butanol is recovered by a condenser.
4. At the end of the reaction, cool down to room temperature, pour the reaction solution into a separatory funnel and wash with water until neutral.
5. The organic layer was dried with anhydrous sodium sulfate, filtered and distilled to obtain the crude product of propyl tert-butyl acetophenone.
6. The crude product was refined to obtain the product of propyl tert-butyl acetophenone with high purity.
3. Precautions
1. The amount of catalyst should be appropriate, too much will lead to equipment corrosion, too little will affect the reaction rate.
2. The reaction temperature and time should be controlled within the appropriate range to ensure the yield and purity of the product.
3. During the washing and drying process, it should be ensured that the product is in full contact with the detergent and desiccant to achieve better washing and drying effect.
4. Safety and environmental protection
1. In the production process, safety operation regulations should be strictly observed to ensure the safety of employees and equipment.
2. Pollutants such as wastewater and exhaust gas produced should be properly treated to meet the national environmental standards.
V. Conclusion
The manufacturing method of propyl tert-butyl acetophenone introduced in this paper has the advantages of easy to obtain raw materials, simple operation, high yield, etc., and is suitable for industrialized production. Meanwhile, safety and environmental protection management should be strengthened in the production process to ensure the quality and environmental friendliness of the product.
