Butyl Isobutyl Phenyl Ketone (BIK) is an important organic chemical raw material, which is widely used in the fields of medicine, pesticide and spice. In this paper, a manufacturing method of Butyl Isobutyl Phenyl Ketone will be introduced.
I. Raw materials and equipment
1. Raw materials: acetophenone, isobutyraldehyde, n-butanol, sulfuric acid, sodium hydroxide.
2. Equipment: reactor, condenser, water separator, stirrer, thermometer, pH meter, vacuum pump.
2. Manufacturing steps
1. Add acetophenone and isobutyraldehyde to the reactor and stir well. Then slowly add sulfuric acid as a catalyst to control the pH between 3-4.
2. Heat the reaction kettle to 60-70°C and react for about 2 hours, then raise the temperature to 80-90°C and continue the reaction for 1-2 hours. During this process, butyl isobutyl acetophenone and water are produced.
3. The water generated is separated out by means of a water separator, and the reactor is then continued to be heated so that the water is completely evaporated.
4. The reaction is stopped by adding sodium hydroxide solution to the reactor and adjusting the pH to neutral.
5. The reaction solution was washed with n-butanol and then distilled to recover the n-butanol to obtain the crude product butyl isobutyl acetophenone.
6. Perform vacuum distillation on the crude product and collect the fraction at the target boiling point, which is the pure butyl isobutyl acetophenone.
3. Precautions
1. Strictly control the order and speed of dosing to avoid local overheating to trigger side reactions.
2. Pay close attention to the change of pH and temperature during the reaction process, and adjust the dosage of catalyst in time.
3. Keep the equipment closed during washing and distillation to prevent the organic solvent from volatilizing and polluting the environment.
4. Operators are required to wear protective gear to avoid contact with toxic and hazardous substances.
4. Yield and purity
The yield of this manufacturing method is about 80-85%, and the purity can be more than 98%. The yield and purity are affected by the quality of raw materials, operating conditions and other factors.
V. Waste treatment and environmental protection
1. Waste water treatment: the water generated by the reaction can be used as industrial water or treated for environmental protection. Wastewater generated in the washing process should be neutralized, precipitated and other treatments to ensure that it meets the emission standards and then discharged.
2. Waste gas treatment: Organic waste gas generated in the reaction process should be treated by adsorption, combustion, etc. to reduce the pollution to the environment.
3. Waste residue treatment: For the waste residue generated, it should be classified and treated, and those that can be recycled should be recycled, and those that can't be recycled should be safely landfilled or incinerated.
VI. Safety and protection
1. Operators need to be professionally trained to understand the nature of butyl isobutyl acetophenone and the safety operation procedures during the manufacturing process.
2. The production site should be equipped with corresponding fire-fighting facilities, such as fire extinguishers and fire hydrants, and ensure their effectiveness.
3. During operation, operators should wear protective glasses, protective gloves and other protective equipment to avoid direct contact with toxic and hazardous substances.
Summary:
This paper describes a manufacturing method of butyl isobutyl acetophenone, which is easy to operate, has a high yield, and is able to obtain a product with high purity. During the production process, safety operation procedures should be strictly observed, and waste treatment and environmental protection should be strengthened to ensure the safety and environmental protection of the production process.
